People Publications

COVID-19 and Hospital-Acquired Delirium J Geriatr Med Gerontol 2020.
Pooja Nair, Aileen Nguyen, Nishita Nigam, Abraham Kanal.

Management of Pneumonia Syndromes in the Hospital: Make Pneumonia Your Best Friend. The Medical clinics of North America 2020.
Kanal A, Sharpe BA, Abelson J.

Adaptability on Shifting Ground: a Rapid Qualitative Assessment of Multi-institutional Inpatient Surge Planning and Workforce Deployment During the COVID-19 Pandemic. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022.
Keniston A, Sakumoto M, Astik GJ, Auerbach A, Eid SM, Kangelaris KN, Kulkarni SA, Lee T, Leykum LK, Linker AS, Worster DT, Burden M.

Peripheral blood leukocyte telomere length is associated with survival of sepsis patients. The European respiratory journal 2020.
Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ.

A conserved immune trajectory of recovery in hospitalized COVID-19 patients. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022.
Burnett CE, Hauge Okholm TL, Tenvooren I, Marquez DM, Tamaki S, Sandoval PM, UCSF COMET Consortium, Calfee CS, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Erle DJ, Ansel KM, Spitzer MH.

Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Critical care (London, England) 2019.
Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD.

Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance In early Human Sepsis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022.
Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA.

The Association between Limited English Proficiency and Sepsis Mortality. Journal of hospital medicine 2019.
Zachary G Jacobs, Priya A Prasad, Margaret C Fang, Yumiko Abe-Jones, Kirsten N Kangelaris.

Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022.
Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group.

ASSOCIATION OF ANGIOPOIETIN-2 AND ATRIAL FIBRILLATION BURDEN IN CRITICALLY ILL PATIENTS. Journal of the American College of Cardiology 2019.
Lily Stern, Kathleen Liu, Hanjing Zhuo, Kirsten Kangelaris, Antonio Gomez, Alejandra Jauregui, Kathryn Vessel, Thomas Deiss, Jason Abbott, Ashish Agrawal, Michael Matthay, Carolyn S. Calfee, Liviu Klein.

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021.
ACTIV-3/Therapeutics for Inpatients with COVID-19 (TICO) Study Group.

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome. Intensive care medicine 2017.
Zhao Z, Wickersham N, Kangelaris KN, May AK, Bernard GR, Matthay MA, Calfee CS, Koyama T, Ware LB.

Responses to a Neutralizing Monoclonal Antibody for Hospitalized Patients With COVID-19 According to Baseline Antibody and Antigen Levels : A Randomized Controlled Trial. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2021.
ACTIV-3/TICO Bamlanivimab Study Group, Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Goodman AL, Chang W, Dewar RL, Gerry NP, Higgs ES, Highbarger H, Murray DD, Murray TA, Natarajan V, Paredes R, Parmar MKB, Phillips AN, Reilly C, Rupert AW, Sharma S, Shaw-Saliba K, Sherman BT, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Davey VJ, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD.

Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. American journal of respiratory and critical care medicine 2017.
Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS, ARDS Network.

Increased rates of secondary bacterial infections, including Enterococcus bacteremia, in patients hospitalized with coronavirus disease 2019 (COVID-19). Infection control and hospital epidemiology 2021.
DeVoe C, Segal MR, Wang L, Stanley K, Madera S, Fan J, Schouest J, Graham-Ojo R, Nichols A, Prasad PA, Ghale R, Love C, Abe-Jones Y, Kangelaris KN, Patterson SL, Yokoe DS, Langelier CR.

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Survey of Anesthesiology 2016.
Kirsten Neudoerffer Kangelaris, Lorraine B. Ware, Chen Yu Wang, David R. Janz, Hanjing Zhuo, Michael A. Matthay, Carolyn S. Calfee.

Agreement Between Sepsis-2 and Sepsis-3 Definitions Among Patients Admitted to the Intensive Care Unit. Annals of the American Thoracic Society 2024.
Zalucky AA, Evrard B, Delucchi K, Zhuo H, Wu N, Liu KD, Hendrickson CM, Matthay MA, Kangelaris KN, Calfee CS.

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01. EClinicalMedicine 2021.
Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Wolfgang P, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B.

The authors reply. Critical care medicine 2016.
Kangelaris KN, Ware LB, Matthay MA, Calfee CS.

Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nature communications 2024.
Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, COMET Consortium, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR.

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nature communications 2021.
Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium , Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR.

The authors reply. Critical care medicine 2016.
Kangelaris KN, Ware LB, Matthay MA, Calfee CS.

Identifying and Measuring Administrative Harms Experienced by Hospitalists and Administrative Leaders. JAMA internal medicine 2024.
Burden M, Astik G, Auerbach A, Bowling G, Kangelaris KN, Keniston A, Kochar A, Leykum LK, Linker AS, Sakumoto M, Rogers K, Schwatka N, Westergaard S.

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19. Science translational medicine 2021.
van der Wijst MGP, Vazquez SE, Hartoularos GC, Bastard P, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Mann SA, Lynch KL, Yun C, Havlir DV, Chamie G, Marquez C, Greenhouse B, Lionakis MS, Norris PJ, Dumont LJ, Kelly K, Zhang P, Zhang Q, Gervais A, Le Voyer T, Whatley A, Si Y, Byrne A, Combes AJ, Rao AA, Song YS, Fragiadakis GK, Kangelaris K, Calfee CS, Erle DJ, Hendrickson C, Krummel MF, Woodruff PG, Langelier CR, Casanova JL, Derisi JL, Anderson MS, Ye CJ, UCSF COMET consortium.

Implementation and evaluation of a "works-in-progress" session to promote scholarship in an academic hospitalist group. Journal of hospital medicine 2016.
Patel H, Fang MC, Harrison JD, Auerbach A, Kangelaris KN.

Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Nature communications 2024.
Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK.

Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. The New England journal of medicine 2021.
REMAP-CAP Investigators , ACTIV-4a Investigators , ATTACC Investigators , Goligher EC, Bradbury CA, McVerry BJ, Lawler PR, Berger JS, Gong MN, Carrier M, Reynolds HR, Kumar A, Turgeon AF, Kornblith LZ, Kahn SR, Marshall JC, Kim KS, Houston BL, Derde LPG, Cushman M, Tritschler T, Angus DC, Godoy LC, McQuilten Z, Kirwan BA, Farkouh ME, Brooks MM, Lewis RJ, Berry LR, Lorenzi E, Gordon AC, Ahuja T, Al-Beidh F, Annane D, Arabi YM, Aryal D, Baumann Kreuziger L, Beane A, Bhimani Z, Bihari S, Billett HH, Bond L, Bonten M, Brunkhorst F, Buxton M, Buzgau A, Castellucci LA, Chekuri S, Chen JT, Cheng AC, Chkhikvadze T, Coiffard B, Contreras A, Costantini TW, de Brouwer S, Detry MA, Duggal A, Džavík V, Effron MB, Eng HF, Escobedo J, Estcourt LJ, Everett BM, Fergusson DA, Fitzgerald M, Fowler RA, Froess JD, Fu Z, Galanaud JP, Galen BT, Gandotra S, Girard TD, Goodman AL, Goossens H, Green C, Greenstein YY, Gross PL, Haniffa R, Hegde SM, Hendrickson CM, Higgins AM, Hindenburg AA, Hope AA, Horowitz JM, Horvat CM, Huang DT, Hudock K, Hunt BJ, Husain M, Hyzy RC, Jacobson JR, Jayakumar D, Keller NM, Khan A, Kim Y, Kindzelski A, King AJ, Knudson MM, Kornblith AE, Kutcher ME, Laffan MA, Lamontagne F, Le Gal G, Leeper CM, Leifer ES, Lim G, Gallego Lima F, Linstrum K, Litton E, Lopez-Sendon J, Lother SA, Marten N, Saud Marinez A, Martinez M, Mateos Garcia E, Mavromichalis S, McAuley DF, McDonald EG, McGlothlin A, McGuinness SP, Middeldorp S, Montgomery SK, Mouncey PR, Murthy S, Nair GB, Nair R, Nichol AD, Nicolau JC, Nunez-Garcia B, Park JJ, Park PK, Parke RL, Parker JC, Parnia S, Paul JD, Pompilio M, Quigley JG, Rosenson RS, Rost NS, Rowan K, Santos FO, Santos M, Santos MO, Satterwhite L, Saunders CT, Schreiber J, Schutgens REG, Seymour CW, Siegal DM, Silva DG, Singhal AB, Slutsky AS, Solvason D, Stanworth SJ, Turner AM, van Bentum-Puijk W, van de Veerdonk FL, van Diepen S, Vazquez-Grande G, Wahid L, Wareham V, Widmer RJ, Wilson JG, Yuriditsky E, Zhong Y, Berry SM, McArthur CJ, Neal MD, Hochman JS, Webb SA, Zarychanski R.

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Critical care medicine 2016.
Kangelaris KN, Ware LB, Wang CY, Janz DR, Zhuo H, Matthay MA, Calfee CS.

Collaborative research: The power of multiorganizational affinity groups and adaptive research methods. Journal of hospital medicine 2024.
Linker AS, Astik GJ, Bowling G, Kangelaris KN, Kara A, Keniston A, Kulkarni SA, Sakumoto M, Schwatka N, Westergaard S, Leykum LK, Auerbach A, Burden M.

An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard. Clinical imaging 2014.
Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR.

Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome. Critical care medicine 2015.
Calfee CS, Matthay MA, Kangelaris KN, Siew ED, Janz DR, Bernard GR, May AK, Jacob P, Havel C, Benowitz NL, Ware LB.

Elevated Hemoglobin A1c and the Risk of Developing ARDS in Two Cohort Studies. CHEST Critical Care 2024.
Bogart AM, Lopez CR, Obeidalla SN, Wang C, Willmore A, Jauregui A, Kangelaris KN, Hendrickson C, Gomez A, Liu KD, Matthay MA, Shaver CM, Bastarache JA, Calfee CS, Kerchberger VE, Ware LB.

Identifying the Sickest During Triage: Using Point-of-Care Severity Scores to Predict Prognosis in Emergency Department Patients With Suspected Sepsis. Journal of hospital medicine 2021.
Prasad PA, Fang MC, Martinez SP, Liu KD, Kangelaris KN.

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies. Chest 2015.
Calfee CS, Janz DR, Bernard GR, May AK, Kangelaris KN, Matthay MA, Ware LB.

Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Critical care (London, England) 2024.
Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS.

Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature 2021.
Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF.

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. American journal of physiology. Lung cellular and molecular physiology 2015.
Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS.

Elevated Hemoglobin A1c and the Risk of Developing Acute Respiratory Distress Syndrome in Two Cohort Studies. CHEST Critical Care 2024.
Avery M. Bogart, Christine R. Lopez, Sarah N. Obeidalla, Chunxue Wang, Andrew Willmore, Alejandra Jauregui, Kirsten N. Kangelaris, Carolyn Hendrickson, Antonio Gomez, Kathleen D. Liu, Michael A. Matthay, Ciara M. Shaver, Julie A. Bastarache, Carolyn S. Calfee, V. Eric Kerchberger, Lorraine B. Ware.

Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids. Critical care explorations 2021.
Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA.

Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive care medicine 2015.
Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA, NHLBI ARDS Network.

Associations Between Volume of Early Intravenous Fluid and Hospital Outcomes in Septic Patients With and Without Heart Failure: A Retrospective Cohort Study. Critical care explorations 2024.
Beagle AJ, Prasad PA, Hubbard CC, Walderich S, Oreper S, Abe-Jones Y, Fang MC, Kangelaris KN.

Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study. Thorax 2021.
Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS.

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive care medicine 2015.
Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA, NHLBI ARDS Network.

Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Critical care (London, England) 2024.
Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS.

Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic. Critical care medicine 2021.
Mathews KS, Seitz KP, Vranas KC, Duggal A, Valley TS, Zhao B, Gundel S, Harhay MO, Chang SY, Hough CL, National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury (PETAL.

From storm to suppression in sepsis: are bands the link?*. Critical care medicine 2014.
Kangelaris KN, Seeley EJ.

Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock. Journal of the American College of Emergency Physicians open 2024.
Prasad PA, Esmaili AM, Oreper S, Beagle AJ, Hubbard C, Raffel KE, Abe-Jones Y, Fang MC, Liu KD, Matthay MA, Kangelaris KN.

Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Research square 2021.
Tsitsiklis A, Zha B, Byrne A, DeVoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Neff N, Sarma A, Serpa P, Deiss T, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay M, Lynch S, DeRisi J, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Rosenberg O, Calfee C, Langelier C.

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Annals of intensive care 2014.
Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA.

Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. American journal of respiratory and critical care medicine 2024.
Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS.

Global absence and targeting of protective immune states in severe COVID-19. 2021.
Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF.

Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. Journal of intensive care 2014.
Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS.

A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience 2023.
Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM.

COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone. 2021.
Sarma A, Christenson S, Mick E, Deiss T, DeVoe C, Pisco A, Ghale R, Jauregui A, Byrne A, Moazed F, Spottiswoode N, Sinha P, Zha B, Neff N, Tan M, Serpa PH, Ansel KM, Wilson J, Leligdowicz A, Seigel E, Sirota M, DeRisi J, Matthay M, Consortium C, Hendrickson C, Kangelaris K, Krummel M, Woodruff P, Erle D, Calfee C, Langelier C.

Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. Journal of critical care 2014.
Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS.

Exploring the Impact of COVID-19 on Women Hospitalists: A Mixed-Gender Qualitative Analysis. Journal of general internal medicine 2023.
Busch JI, Keniston A, Astik GJ, Auerbach A, Kangelaris KN, Kulkarni SA, Leykum LK, Linker AS, Nieto K, Pierce RG, Sakumoto M, Burden M.

Evaluation of a novel metric for personalized opioid prescribing after hospitalization. PloS one 2020.
Iverson NR, Lau CY, Abe-Jones Y, Fang MC, Kangelaris KN, Prasad P, Shah SJ, Najafi N.

Is there still a role for the lung injury score in the era of the Berlin definition ARDS? 2014.
Kangelaris KN, Calfee CS, May AK, Zhuo H, Matthay MA, Ware LB.

Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. The Lancet. Respiratory medicine 2023.
Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS.

A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis. American journal of physiology. Lung cellular and molecular physiology 2020.
Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell CA, Matthay MA.

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome. Intensive care medicine 2014.
Wang CY, Calfee CS, Paul DW, Janz DR, May AK, Zhuo H, Bernard GR, Matthay MA, Ware LB, Kangelaris KN.

Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Research square 2023.
Fragiadakis G, Neyton L, Patel R, Sarma A, Consortium UC, Willmore A, Haller SC, Kangelaris K, Eckalbar W, Erle D, Krummel M, Hendrickson C, Woodruff P, Langelier C, Calfee C.

A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19. The New England journal of medicine 2020.
ACTIV-3/TICO LY-CoV555 Study Group , Lundgren JD, Grund B, Barkauskas CE, Holland TL, Gottlieb RL, Sandkovsky U, Brown SM, Knowlton KU, Self WH, Files DC, Jain MK, Benfield T, Bowdish ME, Leshnower BG, Baker JV, Jensen JU, Gardner EM, Ginde AA, Harris ES, Johansen IS, Markowitz N, Matthay MA, Østergaard L, Chang CC, Davey VJ, Goodman A, Higgs ES, Murray DD, Murray TA, Paredes R, Parmar MKB, Phillips AN, Reilly C, Sharma S, Dewar RL, Teitelbaum M, Wentworth D, Cao H, Klekotka P, Babiker AG, Gelijns AC, Kan VL, Polizzotto MN, Thompson BT, Lane HC, Neaton JD.

Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. American journal of respiratory and critical care medicine 2013.
Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS.

Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Critical care (London, England) 2023.
Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM.

Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA 2020.
Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM.

681. Critical care medicine 2012.
Erika Moseson, Hanjing Zhuo, John Stein, Jeff Chu, Michael Matthay, Kirsten Kangelaris, Kathleen Liu, Carolyn Calfee.

Building a thriving academic hospitalist workforce: A rapid qualitative analysis identifying key areas of focus in the field. Journal of hospital medicine 2023.
Kulkarni SA, Keniston A, Linker AS, Astik GJ, Kangelaris KN, Leykum LK, Sakumoto M, Auerbach A, Burden M.

Alternative Tobacco Product Use in Critically Ill Patients. 2020.
Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS.

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest 2011.
Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA, National Heart, Lung, and Blood Institute ARDS Network.

Severe Recurrence of Reactive Infectious Mucocutaneous Eruption with Extensive Ocular Involvement in an Adult due to SARS-CoV-2. JAAD case reports 2023.
Wu D, Lee EY, Lifton J, Zullo SW, Seiger K, Nadadur R, Fox LP, Escobar DJ, Dobry AS, Yung M, Kangelaris KN, Arakaki RY.

Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses. Nature communications 2020.
Mick E, Kamm J, Pisco AO, Ratnasiri K, Babik JM, Castañeda G, DeRisi JL, Detweiler AM, Hao SL, Kangelaris KN, Kumar GR, Li LM, Mann SA, Neff N, Prasad PA, Serpa PH, Shah SJ, Spottiswoode N, Tan M, Calfee CS, Christenson SA, Kistler A, Langelier C.

FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Annals of intensive care 2011.
Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD.

Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS. American journal of physiology. Lung cellular and molecular physiology 2023.
Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS.

Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury. American journal of physiology. Renal physiology 2020.
Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD.

Association between a serotonin transporter gene variant and hopelessness among men in the Heart and Soul Study. Journal of general internal medicine 2010.
Kangelaris KN, Vittinghoff E, Otte C, Na B, Auerbach AD, Whooley MA.

Practical Applications of Rapid Qualitative Analysis for Operations, Quality Improvement, and Research in Dynamically Changing Hospital Environments. Joint Commission journal on quality and patient safety 2022.
Keniston A, McBeth L, Astik G, Auerbach A, Busch J, Kangelaris KN, Kulkarni SA, Linker AS, Sakumoto M, Leykum L, Burden M.

Clinical features, diagnostics, and outcomes of patients presenting with acute respiratory illness: A retrospective cohort study of patients with and without COVID-19. EClinicalMedicine 2020.
Shah SJ, Barish PN, Prasad PA, Kistler A, Neff N, Kamm J, Li LM, Chiu CY, Babik JM, Fang MC, Kangelaris KN, Langelier C, Abe-Jones Y, Alipanah N, Alvarez FN, Botvinnik OB, Castaneda G.

Genetic Testing Before Anticoagulation? A Systematic Review of Pharmacogenetic Dosing of Warfarin. Journal of general internal medicine 2009.
Kirsten Neudoerffer Kangelaris, Stephen Bent, Robert L. Nussbaum, David A. Garcia, Jeffrey A. Tice.

Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults. Nature microbiology 2022.
Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR.

Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Critical care medicine 2020.
Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS.

Genetic testing before anticoagulation? A systematic review of pharmacogenetic dosing of warfarin. Journal of general internal medicine 2009.
Kangelaris KN, Bent S, Nussbaum RL, Garcia DA, Tice JA.

Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19. Critical care (London, England) 2022.
Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA, COMET Consortium.

Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive care medicine 2020.
Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS.

Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer. JAMA 2007.
Kangelaris KN, Gruber SB.

Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients. Immunity 2022.
Burnett CE, Okholm TLH, Tenvooren I, Marquez DM, Tamaki S, Munoz Sandoval P, Willmore A, UCSF COMET Consortium, Hendrickson CM, Kangelaris KN, Langelier CR, Krummel MF, Woodruff PG, Calfee CS, Erle DJ, Ansel KM, Spitzer MH.

The Association between Limited English Proficiency and Sepsis Mortality. Journal of hospital medicine 2019.
Jacobs ZG, Prasad PA, Fang MC, Abe-Jones Y, Kangelaris KN.

Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. 2015 Year Book of Pediatrics. Ed. Cabana MD. (Elsevier; Philadelphia, PA) 2022.
Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS.

Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment. Critical care medicine 2020.
Prasad PA, Fang MC, Abe-Jones Y, Calfee CS, Matthay MA, Kangelaris KN.

The Importance of Emotional Intelligence When Leading in a Time of Crisis. Journal of hospital medicine 2020.
Kantor MA, Apgar SK, Esmaili AM, Khan A, Monash B, Sharpe BA.

Shared Decision-Making During Inpatient Rounds: Opportunities for Improvement in Patient Engagement and Communication. Journal of hospital medicine 2018.
Blankenburg R, Hilton JF, Yuan P, Rennke S, Monash B, Harman SM, Sakai DS, Hosamani P, Khan A, Chua I, Huynh E, Shieh L, Xie L.

The SDM 3 Circle Model: A Literature Synthesis and Adaptation for Shared Decision Making in the Hospital. Journal of hospital medicine 2017.
Rennke S, Yuan P, Monash B, Blankenburg R, Chua I, Harman S, Sakai DS, Khan A, Hilton JF, Shieh L, Satterfield J.

Letting a Good Crisis Go to Waste. Journal of general internal medicine 2019.
Auerbach AD, Khanna R, Adler-Milstein J.

The Best Laid Plans-Medication Reconciliation Optimization in Theory and Practice. Journal of hospital medicine 2019.
Jue VI, Khanna RR.

Effectiveness of a Best Practice Alert to Reduce Telemetry Orders-Reply. JAMA internal medicine 2019.
Najafi N, Cucina R, Khanna R.

Predictive value of the present-on-admission indicator for hospital-associated hemorrhage. Thrombosis research 2019.
Ghazvinian R, White RH, Gage BF, Fang MC, Saeed R, Khanna RR.

Differences in Narrative Language in Evaluations of Medical Students by Gender and Under-represented Minority Status. Journal of general internal medicine 2019.
Rojek AE, Khanna R, Yim JWL, Gardner R, Lisker S, Hauer KE, Lucey C, Sarkar U.

Assessment of a Targeted Electronic Health Record Intervention to Reduce Telemetry Duration: A Cluster-Randomized Clinical Trial. JAMA internal medicine 2019.
Najafi N, Cucina R, Pierre B, Khanna R.

Balancing Innovation and Safety When Integrating Digital Tools Into Health Care. Annals of internal medicine 2018.
Auerbach AD, Neinstein A, Khanna R.

Electronic Order Volume as a Meaningful Component in Estimating Patient Complexity and Resident Physician Workload. Journal of hospital medicine 2018.
Groningen NV, Prasad PA, Najafi N, Rajkomar A, Khanna RR, Fang MC.